Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali, Tracey

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs. [electronic resource] - ChemMedChem 09 2017 - 1542-1554 p. digital

Publication Type: Journal Article

1860-7187

10.1002/cmdc.201700340 doi


Animals
Binding Sites
Carboxylic Acids--chemistry
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Design
Enzyme Inhibitors--chemistry
Humans
Hydrogen Bonding
Inhibitory Concentration 50
Mice
Microsomes--metabolism
Molecular Dynamics Simulation
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Prodrugs--chemistry
Protein Binding
Protein Isoforms--antagonists & inhibitors
Quinolones--chemistry
Structure-Activity Relationship