Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. [electronic resource]
Producer: 20180406Description: 44255-44265 p. digitalISSN:- 1949-2553
- Animals
- Antineoplastic Agents -- chemistry
- Binding Sites
- Biomarkers, Tumor
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Clomiphene -- chemistry
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- chemistry
- Gene Knockdown Techniques
- Humans
- Inhibitory Concentration 50
- Isocitrate Dehydrogenase -- antagonists & inhibitors
- Male
- Mice
- Models, Molecular
- Molecular Conformation
- Molecular Docking Simulation
- Molecular Dynamics Simulation
- Mutant Proteins
- Protein Binding
- Structure-Activity Relationship
- Substrate Specificity
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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