Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1.
Zheng, Mengzhu
Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. [electronic resource] - Oncotarget Jul 2017 - 44255-44265 p. digital
Publication Type: Journal Article
1949-2553
10.18632/oncotarget.17464 doi
Animals
Antineoplastic Agents--chemistry
Binding Sites
Biomarkers, Tumor
Cell Line, Tumor
Cell Proliferation--drug effects
Clomiphene--chemistry
Enzyme Activation--drug effects
Enzyme Inhibitors--chemistry
Gene Knockdown Techniques
Humans
Inhibitory Concentration 50
Isocitrate Dehydrogenase--antagonists & inhibitors
Male
Mice
Models, Molecular
Molecular Conformation
Molecular Docking Simulation
Molecular Dynamics Simulation
Mutant Proteins
Protein Binding
Structure-Activity Relationship
Substrate Specificity
Xenograft Model Antitumor Assays
Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. [electronic resource] - Oncotarget Jul 2017 - 44255-44265 p. digital
Publication Type: Journal Article
1949-2553
10.18632/oncotarget.17464 doi
Animals
Antineoplastic Agents--chemistry
Binding Sites
Biomarkers, Tumor
Cell Line, Tumor
Cell Proliferation--drug effects
Clomiphene--chemistry
Enzyme Activation--drug effects
Enzyme Inhibitors--chemistry
Gene Knockdown Techniques
Humans
Inhibitory Concentration 50
Isocitrate Dehydrogenase--antagonists & inhibitors
Male
Mice
Models, Molecular
Molecular Conformation
Molecular Docking Simulation
Molecular Dynamics Simulation
Mutant Proteins
Protein Binding
Structure-Activity Relationship
Substrate Specificity
Xenograft Model Antitumor Assays