The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. [electronic resource]
Producer: 20190103Description: 1-19 p. digitalISSN:- 1423-0194
- Antineoplastic Agents -- pharmacology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Drug Therapy, Combination
- E2F1 Transcription Factor -- metabolism
- Fluorouracil -- pharmacology
- Humans
- Isoquinolines -- pharmacology
- Neuroendocrine Tumors -- drug therapy
- Piperazines -- pharmacology
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Retinoblastoma Protein -- metabolism
- Signal Transduction -- drug effects
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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