The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1.
Reuther, Clemens
The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. [electronic resource] - Neuroendocrinology 2018 - 1-19 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1423-0194
10.1159/000453369 doi
Antineoplastic Agents--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclin-Dependent Kinase Inhibitor p21--metabolism
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Drug Therapy, Combination
E2F1 Transcription Factor--metabolism
Fluorouracil--pharmacology
Humans
Isoquinolines--pharmacology
Neuroendocrine Tumors--drug therapy
Piperazines--pharmacology
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Retinoblastoma Protein--metabolism
Signal Transduction--drug effects
Tumor Suppressor Protein p53--genetics
The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. [electronic resource] - Neuroendocrinology 2018 - 1-19 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1423-0194
10.1159/000453369 doi
Antineoplastic Agents--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclin-Dependent Kinase Inhibitor p21--metabolism
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Drug Therapy, Combination
E2F1 Transcription Factor--metabolism
Fluorouracil--pharmacology
Humans
Isoquinolines--pharmacology
Neuroendocrine Tumors--drug therapy
Piperazines--pharmacology
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Retinoblastoma Protein--metabolism
Signal Transduction--drug effects
Tumor Suppressor Protein p53--genetics