Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer. [electronic resource]
Producer: 20171220Description: 18-37 p. digitalISSN:- 1096-1186
- Animals
- Benserazide -- pharmacology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Colonic Neoplasms -- drug therapy
- Coumarins -- pharmacology
- Cystathionine beta-Synthase -- antagonists & inhibitors
- Drug Repositioning -- methods
- Energy Metabolism -- drug effects
- Female
- HCT116 Cells
- HT29 Cells
- Humans
- Hydrazines -- pharmacology
- Hydrogen Sulfide -- metabolism
- Male
- Mice
- Mice, Nude
- Mitochondria -- drug effects
- Morpholines -- pharmacology
- Organothiophosphorus Compounds -- pharmacology
- Therapies, Investigational -- methods
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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