Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.
Druzhyna, Nadiya
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer. [electronic resource] - Pharmacological research 11 2016 - 18-37 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1096-1186
10.1016/j.phrs.2016.08.016 doi
Animals
Benserazide--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
Colonic Neoplasms--drug therapy
Coumarins--pharmacology
Cystathionine beta-Synthase--antagonists & inhibitors
Drug Repositioning--methods
Energy Metabolism--drug effects
Female
HCT116 Cells
HT29 Cells
Humans
Hydrazines--pharmacology
Hydrogen Sulfide--metabolism
Male
Mice
Mice, Nude
Mitochondria--drug effects
Morpholines--pharmacology
Organothiophosphorus Compounds--pharmacology
Therapies, Investigational--methods
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer. [electronic resource] - Pharmacological research 11 2016 - 18-37 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1096-1186
10.1016/j.phrs.2016.08.016 doi
Animals
Benserazide--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
Colonic Neoplasms--drug therapy
Coumarins--pharmacology
Cystathionine beta-Synthase--antagonists & inhibitors
Drug Repositioning--methods
Energy Metabolism--drug effects
Female
HCT116 Cells
HT29 Cells
Humans
Hydrazines--pharmacology
Hydrogen Sulfide--metabolism
Male
Mice
Mice, Nude
Mitochondria--drug effects
Morpholines--pharmacology
Organothiophosphorus Compounds--pharmacology
Therapies, Investigational--methods