A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. [electronic resource]
Producer: 20161213Description: 12724-12731 p. digitalISSN:- 1083-351X
- 5-Lipoxygenase-Activating Protein Inhibitors -- chemistry
- 5-Lipoxygenase-Activating Proteins -- chemistry
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Binding Sites -- genetics
- Biocatalysis -- drug effects
- Crystallography, X-Ray
- Dogs
- Enzyme Assays -- methods
- Humans
- Indoles -- chemistry
- Mice
- Models, Molecular
- Molecular Structure
- Mutation
- Protein Binding
- Protein Domains
- Quinolines -- chemistry
- Rats
- Sequence Homology, Amino Acid
- Species Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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