A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.

Blevitt, Jonathan M

A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. [electronic resource] - The Journal of biological chemistry Jun 2016 - 12724-12731 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M116.725325 doi


5-Lipoxygenase-Activating Protein Inhibitors--chemistry
5-Lipoxygenase-Activating Proteins--chemistry
Amino Acid Sequence
Amino Acid Substitution
Animals
Binding Sites--genetics
Biocatalysis--drug effects
Crystallography, X-Ray
Dogs
Enzyme Assays--methods
Humans
Indoles--chemistry
Mice
Models, Molecular
Molecular Structure
Mutation
Protein Binding
Protein Domains
Quinolines--chemistry
Rats
Sequence Homology, Amino Acid
Species Specificity