Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives. [electronic resource]
Producer: 20161213Description: 50-62 p. digitalISSN:- 1768-3254
- Antineoplastic Agents -- chemical synthesis
- Catalytic Domain -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drug Design
- Drug Screening Assays, Antitumor
- Humans
- Hydrophobic and Hydrophilic Interactions
- Molecular Structure
- Phthalazines -- chemical synthesis
- Protein Kinase Inhibitors -- chemical synthesis
- Structure-Activity Relationship
- Vascular Endothelial Growth Factor Receptor-2 -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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