Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives.

Eldehna, Wagdy M

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives. [electronic resource] - European journal of medicinal chemistry May 2016 - 50-62 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1768-3254

10.1016/j.ejmech.2016.02.029 doi


Antineoplastic Agents--chemical synthesis
Catalytic Domain--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
Humans
Hydrophobic and Hydrophilic Interactions
Molecular Structure
Phthalazines--chemical synthesis
Protein Kinase Inhibitors--chemical synthesis
Structure-Activity Relationship
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors