Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas. [electronic resource]
Producer: 20160620Description: 582-7 p. digitalISSN:- 1097-0142
- Adult
- Aged
- Alanine Transaminase -- blood
- Anilides -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols -- administration & dosage
- Aspartate Aminotransferases -- blood
- Astrocytoma -- pathology
- Brain Neoplasms -- pathology
- Chemoradiotherapy -- methods
- Chemoradiotherapy, Adjuvant -- methods
- Constipation -- chemically induced
- Dacarbazine -- administration & dosage
- Diarrhea
- Fatigue -- chemically induced
- Female
- Glioblastoma -- pathology
- Humans
- Hypertension -- chemically induced
- L-Lactate Dehydrogenase -- blood
- Leukopenia
- Maintenance Chemotherapy -- methods
- Male
- Maximum Tolerated Dose
- Middle Aged
- Nausea -- chemically induced
- Neoplasm Grading
- Neurosurgical Procedures
- Neutropenia
- Pyridines -- administration & dosage
- Temozolomide
- Thrombocytopenia -- chemically induced
- Treatment Outcome
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Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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