Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas.

Schiff, David

Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas. [electronic resource] - Cancer Feb 2016 - 582-7 p. digital

Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

1097-0142

10.1002/cncr.29798 doi


Adult
Aged
Alanine Transaminase--blood
Anilides--administration & dosage
Antineoplastic Combined Chemotherapy Protocols--administration & dosage
Aspartate Aminotransferases--blood
Astrocytoma--pathology
Brain Neoplasms--pathology
Chemoradiotherapy--methods
Chemoradiotherapy, Adjuvant--methods
Constipation--chemically induced
Dacarbazine--administration & dosage
Diarrhea
Fatigue--chemically induced
Female
Glioblastoma--pathology
Humans
Hypertension--chemically induced
L-Lactate Dehydrogenase--blood
Leukopenia
Maintenance Chemotherapy--methods
Male
Maximum Tolerated Dose
Middle Aged
Nausea--chemically induced
Neoplasm Grading
Neurosurgical Procedures
Neutropenia
Pyridines--administration & dosage
Temozolomide
Thrombocytopenia--chemically induced
Treatment Outcome