Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL. [electronic resource]
Producer: 20150825Description: 605-19 p. digitalISSN:- 0006-3002
- Animals
- Biological Transport
- Biotransformation
- Cell Death
- Cell Line
- Cholesterol, HDL -- metabolism
- Chromatography, High Pressure Liquid
- Enzyme Inhibitors -- pharmacology
- Esterification
- Fatty Acids -- metabolism
- Group IV Phospholipases A2 -- antagonists & inhibitors
- Humans
- Ketocholesterols -- metabolism
- Macaca mulatta
- Male
- Mass Spectrometry
- RNA Interference
- Retinal Pigment Epithelium -- drug effects
- Sterol O-Acyltransferase -- antagonists & inhibitors
- Time Factors
- Transfection
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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