Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL.
Lee, Jung Wha
Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL. [electronic resource] - Biochimica et biophysica acta May 2015 - 605-19 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
0006-3002
10.1016/j.bbalip.2015.01.007 doi
Animals
Biological Transport
Biotransformation
Cell Death
Cell Line
Cholesterol, HDL--metabolism
Chromatography, High Pressure Liquid
Enzyme Inhibitors--pharmacology
Esterification
Fatty Acids--metabolism
Group IV Phospholipases A2--antagonists & inhibitors
Humans
Ketocholesterols--metabolism
Macaca mulatta
Male
Mass Spectrometry
RNA Interference
Retinal Pigment Epithelium--drug effects
Sterol O-Acyltransferase--antagonists & inhibitors
Time Factors
Transfection
Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL. [electronic resource] - Biochimica et biophysica acta May 2015 - 605-19 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
0006-3002
10.1016/j.bbalip.2015.01.007 doi
Animals
Biological Transport
Biotransformation
Cell Death
Cell Line
Cholesterol, HDL--metabolism
Chromatography, High Pressure Liquid
Enzyme Inhibitors--pharmacology
Esterification
Fatty Acids--metabolism
Group IV Phospholipases A2--antagonists & inhibitors
Humans
Ketocholesterols--metabolism
Macaca mulatta
Male
Mass Spectrometry
RNA Interference
Retinal Pigment Epithelium--drug effects
Sterol O-Acyltransferase--antagonists & inhibitors
Time Factors
Transfection