A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling. [electronic resource]
Producer: 20150624Description: 318-26 p. digitalISSN:- 1460-2180
- Animals
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors -- metabolism
- Cell Proliferation -- drug effects
- Colorectal Neoplasms -- drug therapy
- Diterpenes, Kaurane -- chemistry
- Drug Screening Assays, Antitumor
- Gene Expression Regulation, Neoplastic -- drug effects
- HCT116 Cells -- drug effects
- Humans
- Mice, Inbred BALB C
- Molecular Docking Simulation
- Molecular Targeted Therapy
- Transcription Factor 4
- Transcription Factors -- metabolism
- Tumor Cells, Cultured
- Wnt Signaling Pathway -- drug effects
- Xenograft Model Antitumor Assays
- beta Catenin -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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