A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling.
Ye, Qi
A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling. [electronic resource] - Carcinogenesis Mar 2015 - 318-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1460-2180
10.1093/carcin/bgv003 doi
Animals
Antineoplastic Agents, Phytogenic--pharmacology
Apoptosis--drug effects
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors--metabolism
Cell Proliferation--drug effects
Colorectal Neoplasms--drug therapy
Diterpenes, Kaurane--chemistry
Drug Screening Assays, Antitumor
Gene Expression Regulation, Neoplastic--drug effects
HCT116 Cells--drug effects
Humans
Mice, Inbred BALB C
Molecular Docking Simulation
Molecular Targeted Therapy
Transcription Factor 4
Transcription Factors--metabolism
Tumor Cells, Cultured
Wnt Signaling Pathway--drug effects
Xenograft Model Antitumor Assays
beta Catenin--antagonists & inhibitors
A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling. [electronic resource] - Carcinogenesis Mar 2015 - 318-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1460-2180
10.1093/carcin/bgv003 doi
Animals
Antineoplastic Agents, Phytogenic--pharmacology
Apoptosis--drug effects
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors--metabolism
Cell Proliferation--drug effects
Colorectal Neoplasms--drug therapy
Diterpenes, Kaurane--chemistry
Drug Screening Assays, Antitumor
Gene Expression Regulation, Neoplastic--drug effects
HCT116 Cells--drug effects
Humans
Mice, Inbred BALB C
Molecular Docking Simulation
Molecular Targeted Therapy
Transcription Factor 4
Transcription Factors--metabolism
Tumor Cells, Cultured
Wnt Signaling Pathway--drug effects
Xenograft Model Antitumor Assays
beta Catenin--antagonists & inhibitors