Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia. [electronic resource]
Producer: 20150723Description: 16-24 p. digitalISSN:- 2213-6711
- Biomarkers
- Cell Differentiation
- Cell Line
- Frontotemporal Dementia -- genetics
- Gene Expression
- Gene Expression Profiling
- Haploinsufficiency
- Humans
- Induced Pluripotent Stem Cells -- cytology
- Intercellular Signaling Peptides and Proteins -- genetics
- Mutation
- Neural Stem Cells -- cytology
- Neurogenesis -- genetics
- Neurons -- metabolism
- Phenotype
- Progranulins
- Time Factors
- Transcription, Genetic
- Transcriptome
- Wnt Signaling Pathway
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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