Withaferin A abolishes the stem cell factor-stimulated pigmentation of human epidermal equivalents by interrupting the auto-phosphorylation of c-KIT in human melanocytes. [electronic resource]
Producer: 20150909Description: 73-88 p. digitalISSN:- 1432-069X
- Cells, Cultured
- Coculture Techniques
- Dose-Response Relationship, Drug
- Enzyme Activation
- Epidermal Cells
- Epidermis -- drug effects
- Gene Expression Regulation
- Humans
- Melanins -- biosynthesis
- Melanocytes -- drug effects
- Monophenol Monooxygenase -- genetics
- Phosphorylation
- Protein Binding
- Proto-Oncogene Proteins c-kit -- metabolism
- Signal Transduction -- drug effects
- Skin Lightening Preparations -- pharmacology
- Skin Pigmentation -- drug effects
- Stem Cell Factor -- metabolism
- Time Factors
- Withanolides -- pharmacology
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Publication Type: Journal Article
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