Withaferin A abolishes the stem cell factor-stimulated pigmentation of human epidermal equivalents by interrupting the auto-phosphorylation of c-KIT in human melanocytes.
Terazawa, Shuko
Withaferin A abolishes the stem cell factor-stimulated pigmentation of human epidermal equivalents by interrupting the auto-phosphorylation of c-KIT in human melanocytes. [electronic resource] - Archives of dermatological research Jan 2015 - 73-88 p. digital
Publication Type: Journal Article
1432-069X
10.1007/s00403-014-1518-y doi
Cells, Cultured
Coculture Techniques
Dose-Response Relationship, Drug
Enzyme Activation
Epidermal Cells
Epidermis--drug effects
Gene Expression Regulation
Humans
Melanins--biosynthesis
Melanocytes--drug effects
Monophenol Monooxygenase--genetics
Phosphorylation
Protein Binding
Proto-Oncogene Proteins c-kit--metabolism
Signal Transduction--drug effects
Skin Lightening Preparations--pharmacology
Skin Pigmentation--drug effects
Stem Cell Factor--metabolism
Time Factors
Withanolides--pharmacology
Withaferin A abolishes the stem cell factor-stimulated pigmentation of human epidermal equivalents by interrupting the auto-phosphorylation of c-KIT in human melanocytes. [electronic resource] - Archives of dermatological research Jan 2015 - 73-88 p. digital
Publication Type: Journal Article
1432-069X
10.1007/s00403-014-1518-y doi
Cells, Cultured
Coculture Techniques
Dose-Response Relationship, Drug
Enzyme Activation
Epidermal Cells
Epidermis--drug effects
Gene Expression Regulation
Humans
Melanins--biosynthesis
Melanocytes--drug effects
Monophenol Monooxygenase--genetics
Phosphorylation
Protein Binding
Proto-Oncogene Proteins c-kit--metabolism
Signal Transduction--drug effects
Skin Lightening Preparations--pharmacology
Skin Pigmentation--drug effects
Stem Cell Factor--metabolism
Time Factors
Withanolides--pharmacology