Isoflurane but not sevoflurane or desflurane aggravates injury to neurons in vitro and in vivo via p75NTR-NF-ĸB activation. [electronic resource]
Producer: 20150115Description: 1429-41 p. digitalISSN:- 1526-7598
- Anesthetics, Inhalation -- toxicity
- Animals
- Binding Sites
- Cell Death -- drug effects
- Cell Hypoxia
- Cell Line, Tumor
- Desflurane
- Dose-Response Relationship, Drug
- Female
- Glucose -- deficiency
- Humans
- Isoflurane -- analogs & derivatives
- Male
- Methyl Ethers -- toxicity
- NF-kappa B -- metabolism
- Nerve Tissue Proteins -- antagonists & inhibitors
- Neurons -- drug effects
- Peptide Fragments -- pharmacology
- Promoter Regions, Genetic
- RNA Interference
- Rats, Sprague-Dawley
- Receptors, Growth Factor
- Receptors, Nerve Growth Factor -- antagonists & inhibitors
- Reperfusion Injury -- chemically induced
- Retinal Diseases -- chemically induced
- Retinal Ganglion Cells -- drug effects
- Sevoflurane
- Signal Transduction -- drug effects
- Transfection
- tat Gene Products, Human Immunodeficiency Virus -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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