Isoflurane but not sevoflurane or desflurane aggravates injury to neurons in vitro and in vivo via p75NTR-NF-ĸB activation.

Schallner, Nils

Isoflurane but not sevoflurane or desflurane aggravates injury to neurons in vitro and in vivo via p75NTR-NF-ĸB activation. [electronic resource] - Anesthesia and analgesia Dec 2014 - 1429-41 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1526-7598

10.1213/ANE.0000000000000488 doi


Anesthetics, Inhalation--toxicity
Animals
Binding Sites
Cell Death--drug effects
Cell Hypoxia
Cell Line, Tumor
Desflurane
Dose-Response Relationship, Drug
Female
Glucose--deficiency
Humans
Isoflurane--analogs & derivatives
Male
Methyl Ethers--toxicity
NF-kappa B--metabolism
Nerve Tissue Proteins--antagonists & inhibitors
Neurons--drug effects
Peptide Fragments--pharmacology
Promoter Regions, Genetic
RNA Interference
Rats, Sprague-Dawley
Receptors, Growth Factor
Receptors, Nerve Growth Factor--antagonists & inhibitors
Reperfusion Injury--chemically induced
Retinal Diseases--chemically induced
Retinal Ganglion Cells--drug effects
Sevoflurane
Signal Transduction--drug effects
Transfection
tat Gene Products, Human Immunodeficiency Virus--pharmacology