Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis. [electronic resource]
Producer: 20150127Description: 1162-73 p. digitalISSN:- 1949-2553
- Animals
- Antineoplastic Agents -- therapeutic use
- Apoptosis -- genetics
- Breast Neoplasms -- drug therapy
- Butadienes -- pharmacology
- Cell Hypoxia
- Enzyme Inhibitors -- pharmacology
- Gene Knockdown Techniques
- Heterografts
- Humans
- Hydrogen-Ion Concentration
- MAP Kinase Signaling System -- drug effects
- MCF-7 Cells
- Macrolides -- pharmacology
- Membrane Proteins -- genetics
- Mice
- Neoplasm Metastasis
- Niacinamide -- analogs & derivatives
- Nitriles -- pharmacology
- Phenylurea Compounds -- therapeutic use
- Proto-Oncogene Proteins -- genetics
- Sorafenib
- Tumor Burden -- drug effects
- Vacuolar Proton-Translocating ATPases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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