Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis.
Graham, Regina M
Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis. [electronic resource] - Oncotarget Mar 2014 - 1162-73 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.1699 doi
Animals
Antineoplastic Agents--therapeutic use
Apoptosis--genetics
Breast Neoplasms--drug therapy
Butadienes--pharmacology
Cell Hypoxia
Enzyme Inhibitors--pharmacology
Gene Knockdown Techniques
Heterografts
Humans
Hydrogen-Ion Concentration
MAP Kinase Signaling System--drug effects
MCF-7 Cells
Macrolides--pharmacology
Membrane Proteins--genetics
Mice
Neoplasm Metastasis
Niacinamide--analogs & derivatives
Nitriles--pharmacology
Phenylurea Compounds--therapeutic use
Proto-Oncogene Proteins--genetics
Sorafenib
Tumor Burden--drug effects
Vacuolar Proton-Translocating ATPases--antagonists & inhibitors
Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis. [electronic resource] - Oncotarget Mar 2014 - 1162-73 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.1699 doi
Animals
Antineoplastic Agents--therapeutic use
Apoptosis--genetics
Breast Neoplasms--drug therapy
Butadienes--pharmacology
Cell Hypoxia
Enzyme Inhibitors--pharmacology
Gene Knockdown Techniques
Heterografts
Humans
Hydrogen-Ion Concentration
MAP Kinase Signaling System--drug effects
MCF-7 Cells
Macrolides--pharmacology
Membrane Proteins--genetics
Mice
Neoplasm Metastasis
Niacinamide--analogs & derivatives
Nitriles--pharmacology
Phenylurea Compounds--therapeutic use
Proto-Oncogene Proteins--genetics
Sorafenib
Tumor Burden--drug effects
Vacuolar Proton-Translocating ATPases--antagonists & inhibitors