The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans. [electronic resource]
Producer: 20141028Description: 759-73 p. digitalISSN:- 1521-009X
- Aryl Hydrocarbon Hydroxylases -- metabolism
- Biotransformation
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP3A -- metabolism
- Feces -- chemistry
- Female
- Humans
- Janus Kinases -- antagonists & inhibitors
- Liver -- enzymology
- Magnetic Resonance Spectroscopy
- Male
- Metabolic Clearance Rate
- Microsomes, Liver -- enzymology
- Piperidines -- blood
- Protein Kinase Inhibitors -- blood
- Pyrimidines -- blood
- Pyrroles -- blood
- Tandem Mass Spectrometry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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