The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.
Dowty, Martin E
The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Apr 2014 - 759-73 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.113.054940 doi
Aryl Hydrocarbon Hydroxylases--metabolism
Biotransformation
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP3A--metabolism
Feces--chemistry
Female
Humans
Janus Kinases--antagonists & inhibitors
Liver--enzymology
Magnetic Resonance Spectroscopy
Male
Metabolic Clearance Rate
Microsomes, Liver--enzymology
Piperidines--blood
Protein Kinase Inhibitors--blood
Pyrimidines--blood
Pyrroles--blood
Tandem Mass Spectrometry
The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Apr 2014 - 759-73 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.113.054940 doi
Aryl Hydrocarbon Hydroxylases--metabolism
Biotransformation
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP3A--metabolism
Feces--chemistry
Female
Humans
Janus Kinases--antagonists & inhibitors
Liver--enzymology
Magnetic Resonance Spectroscopy
Male
Metabolic Clearance Rate
Microsomes, Liver--enzymology
Piperidines--blood
Protein Kinase Inhibitors--blood
Pyrimidines--blood
Pyrroles--blood
Tandem Mass Spectrometry