Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells. [electronic resource]
Producer: 20140110Description: e64835 p. digitalISSN:- 1932-6203
- Cell Degranulation -- drug effects
- Cell Hypoxia -- drug effects
- Cell Membrane -- drug effects
- Cytotoxicity, Immunologic -- drug effects
- Granzymes -- metabolism
- Histocompatibility Antigens Class I -- metabolism
- Humans
- Interleukin-2 -- pharmacology
- K562 Cells
- Killer Cells, Natural -- drug effects
- Ligands
- Lymphocyte Activation -- drug effects
- Multiple Myeloma -- immunology
- NK Cell Lectin-Like Receptor Subfamily K -- metabolism
- Oxygen -- metabolism
- Perforin -- metabolism
- Receptors, IgG -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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