Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells.
Sarkar, Subhashis
Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells. [electronic resource] - PloS one 2013 - e64835 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0064835 doi
Cell Degranulation--drug effects
Cell Hypoxia--drug effects
Cell Membrane--drug effects
Cytotoxicity, Immunologic--drug effects
Granzymes--metabolism
Histocompatibility Antigens Class I--metabolism
Humans
Interleukin-2--pharmacology
K562 Cells
Killer Cells, Natural--drug effects
Ligands
Lymphocyte Activation--drug effects
Multiple Myeloma--immunology
NK Cell Lectin-Like Receptor Subfamily K--metabolism
Oxygen--metabolism
Perforin--metabolism
Receptors, IgG--metabolism
Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells. [electronic resource] - PloS one 2013 - e64835 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0064835 doi
Cell Degranulation--drug effects
Cell Hypoxia--drug effects
Cell Membrane--drug effects
Cytotoxicity, Immunologic--drug effects
Granzymes--metabolism
Histocompatibility Antigens Class I--metabolism
Humans
Interleukin-2--pharmacology
K562 Cells
Killer Cells, Natural--drug effects
Ligands
Lymphocyte Activation--drug effects
Multiple Myeloma--immunology
NK Cell Lectin-Like Receptor Subfamily K--metabolism
Oxygen--metabolism
Perforin--metabolism
Receptors, IgG--metabolism