Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. [electronic resource]
Producer: 20130618Description: 9 p. digitalISSN:- 1476-4598
- Animals
- Anticarcinogenic Agents -- administration & dosage
- Antineoplastic Agents, Hormonal -- administration & dosage
- Azacitidine -- analogs & derivatives
- Breast Neoplasms -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- DNA (Cytosine-5-)-Methyltransferase 1
- DNA (Cytosine-5-)-Methyltransferases -- metabolism
- Decitabine
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Epigenesis, Genetic -- drug effects
- Estradiol -- pharmacology
- Estrogen Receptor alpha -- genetics
- Female
- Gene Expression -- drug effects
- Genistein -- administration & dosage
- Histone Deacetylase 1 -- metabolism
- Histone Deacetylase Inhibitors -- pharmacology
- Histones -- metabolism
- Humans
- Hydroxamic Acids -- pharmacology
- Mice
- Mice, Nude
- Mice, Transgenic
- Proliferating Cell Nuclear Antigen -- metabolism
- Promoter Regions, Genetic
- Tamoxifen -- administration & dosage
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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