Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer.

Li, Yuanyuan

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. [electronic resource] - Molecular cancer Feb 2013 - 9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-4598

10.1186/1476-4598-12-9 doi


Animals
Anticarcinogenic Agents--administration & dosage
Antineoplastic Agents, Hormonal--administration & dosage
Azacitidine--analogs & derivatives
Breast Neoplasms--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
DNA (Cytosine-5-)-Methyltransferase 1
DNA (Cytosine-5-)-Methyltransferases--metabolism
Decitabine
Drug Resistance, Neoplasm--drug effects
Drug Synergism
Epigenesis, Genetic--drug effects
Estradiol--pharmacology
Estrogen Receptor alpha--genetics
Female
Gene Expression--drug effects
Genistein--administration & dosage
Histone Deacetylase 1--metabolism
Histone Deacetylase Inhibitors--pharmacology
Histones--metabolism
Humans
Hydroxamic Acids--pharmacology
Mice
Mice, Nude
Mice, Transgenic
Proliferating Cell Nuclear Antigen--metabolism
Promoter Regions, Genetic
Tamoxifen--administration & dosage
Tumor Burden--drug effects
Xenograft Model Antitumor Assays