Proteostasis modulators prolong missense VHL protein activity and halt tumor progression. [electronic resource]
Producer: 20130716Description: 52-9 p. digitalISSN:- 2211-1247
- Animals
- Cell Line
- Cell Proliferation -- drug effects
- Disease Progression
- Gene Expression Regulation, Neoplastic -- drug effects
- Half-Life
- Histone Deacetylase Inhibitors -- pharmacology
- Humans
- Mice
- Mutant Proteins -- metabolism
- Mutation, Missense -- genetics
- Neoplasms -- genetics
- Protein Stability -- drug effects
- Proteolysis -- drug effects
- RNA, Messenger -- genetics
- Von Hippel-Lindau Tumor Suppressor Protein -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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