Proteostasis modulators prolong missense VHL protein activity and halt tumor progression.

Yang, Chunzhang

Proteostasis modulators prolong missense VHL protein activity and halt tumor progression. [electronic resource] - Cell reports Jan 2013 - 52-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural

2211-1247

10.1016/j.celrep.2012.12.007 doi


Animals
Cell Line
Cell Proliferation--drug effects
Disease Progression
Gene Expression Regulation, Neoplastic--drug effects
Half-Life
Histone Deacetylase Inhibitors--pharmacology
Humans
Mice
Mutant Proteins--metabolism
Mutation, Missense--genetics
Neoplasms--genetics
Protein Stability--drug effects
Proteolysis--drug effects
RNA, Messenger--genetics
Von Hippel-Lindau Tumor Suppressor Protein--genetics