Synthesis and structure-activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: application of weakly basic sulfoximine group as novel S4 binding element. [electronic resource]
Producer: 20130516Description: 136-52 p. digitalISSN:- 1768-3254
- Animals
- Anticoagulants -- administration & dosage
- Binding Sites -- drug effects
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Factor Xa Inhibitors
- Humans
- Imines -- chemistry
- Male
- Models, Molecular
- Molecular Structure
- Rats
- Rats, Wistar
- Reference Values
- Serine Proteases -- metabolism
- Serine Proteinase Inhibitors -- administration & dosage
- Structure-Activity Relationship
- Sulfoxides -- chemistry
- Venous Thrombosis -- drug therapy
- ortho-Aminobenzoates -- administration & dosage
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Publication Type: Journal Article
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