Synthesis and structure-activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: application of weakly basic sulfoximine group as novel S4 binding element.

Pandya, Vrajesh

Synthesis and structure-activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: application of weakly basic sulfoximine group as novel S4 binding element. [electronic resource] - European journal of medicinal chemistry Dec 2012 - 136-52 p. digital

Publication Type: Journal Article

1768-3254

10.1016/j.ejmech.2012.10.005 doi


Animals
Anticoagulants--administration & dosage
Binding Sites--drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Factor Xa Inhibitors
Humans
Imines--chemistry
Male
Models, Molecular
Molecular Structure
Rats
Rats, Wistar
Reference Values
Serine Proteases--metabolism
Serine Proteinase Inhibitors--administration & dosage
Structure-Activity Relationship
Sulfoxides--chemistry
Venous Thrombosis--drug therapy
ortho-Aminobenzoates--administration & dosage