Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis. [electronic resource]
Producer: 20130509Description: 14-9 p. digitalISSN:- 1473-5741
- Antineoplastic Agents -- administration & dosage
- Apoptosis -- drug effects
- Cathepsin B -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- Chloroquine -- pharmacology
- Drug Resistance, Neoplasm -- drug effects
- Furans -- administration & dosage
- Humans
- Intracellular Membranes -- drug effects
- Lung Neoplasms -- drug therapy
- Lysosomal-Associated Membrane Protein 1 -- genetics
- Lysosomes -- drug effects
- Permeability
- Phosphoinositide-3 Kinase Inhibitors
- Pyridines -- administration & dosage
- Pyrimidines -- administration & dosage
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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