Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis.
Enzenmüller, Stefanie
Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis. [electronic resource] - Anti-cancer drugs Jan 2013 - 14-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1473-5741
10.1097/CAD.0b013e32835a36db doi
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
Cathepsin B--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Chloroquine--pharmacology
Drug Resistance, Neoplasm--drug effects
Furans--administration & dosage
Humans
Intracellular Membranes--drug effects
Lung Neoplasms--drug therapy
Lysosomal-Associated Membrane Protein 1--genetics
Lysosomes--drug effects
Permeability
Phosphoinositide-3 Kinase Inhibitors
Pyridines--administration & dosage
Pyrimidines--administration & dosage
TOR Serine-Threonine Kinases--antagonists & inhibitors
Up-Regulation--drug effects
Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis. [electronic resource] - Anti-cancer drugs Jan 2013 - 14-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1473-5741
10.1097/CAD.0b013e32835a36db doi
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
Cathepsin B--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Chloroquine--pharmacology
Drug Resistance, Neoplasm--drug effects
Furans--administration & dosage
Humans
Intracellular Membranes--drug effects
Lung Neoplasms--drug therapy
Lysosomal-Associated Membrane Protein 1--genetics
Lysosomes--drug effects
Permeability
Phosphoinositide-3 Kinase Inhibitors
Pyridines--administration & dosage
Pyrimidines--administration & dosage
TOR Serine-Threonine Kinases--antagonists & inhibitors
Up-Regulation--drug effects