Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity. [electronic resource]
Producer: 20130801Description: 507-13 p. digitalISSN:- 1432-1041
- Adult
- Area Under Curve
- Biotransformation
- Cross-Over Studies
- Cytochrome P-450 CYP3A -- biosynthesis
- Cytochrome P-450 CYP3A Inhibitors
- Drug Administration Schedule
- Drug Interactions
- Enzyme Induction
- Enzyme Inhibitors -- administration & dosage
- Germany
- Humans
- Hydroxylation
- Hypericum
- Ketoconazole -- administration & dosage
- Male
- Metabolic Clearance Rate
- Midazolam -- administration & dosage
- Middle Aged
- Plant Extracts -- administration & dosage
- Plants, Medicinal
- Pregnane X Receptor
- Receptors, Steroid -- drug effects
- Substrate Specificity
- Transcription, Genetic -- drug effects
- Young Adult
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Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial
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