Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity.

Fuchs, Ines

Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity. [electronic resource] - European journal of clinical pharmacology Mar 2013 - 507-13 p. digital

Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial

1432-1041

10.1007/s00228-012-1388-1 doi


Adult
Area Under Curve
Biotransformation
Cross-Over Studies
Cytochrome P-450 CYP3A--biosynthesis
Cytochrome P-450 CYP3A Inhibitors
Drug Administration Schedule
Drug Interactions
Enzyme Induction
Enzyme Inhibitors--administration & dosage
Germany
Humans
Hydroxylation
Hypericum
Ketoconazole--administration & dosage
Male
Metabolic Clearance Rate
Midazolam--administration & dosage
Middle Aged
Plant Extracts--administration & dosage
Plants, Medicinal
Pregnane X Receptor
Receptors, Steroid--drug effects
Substrate Specificity
Transcription, Genetic--drug effects
Young Adult