Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. [electronic resource]
Producer: 20121211Description: 14230-5 p. digitalISSN:- 1091-6490
- Animals
- Astrocytes -- cytology
- Brain-Derived Neurotrophic Factor -- deficiency
- Cell Death -- drug effects
- Cells, Cultured
- Disease Models, Animal
- Excitatory Amino Acid Agonists -- toxicity
- Female
- Fingolimod Hydrochloride
- Immunosuppressive Agents -- pharmacology
- MAP Kinase Signaling System -- drug effects
- Methyl-CpG-Binding Protein 2 -- genetics
- Mice
- Motor Activity -- drug effects
- N-Methylaspartate -- toxicity
- Neurons -- cytology
- Organ Culture Techniques
- Pregnancy
- Propylene Glycols -- pharmacology
- Receptors, Lysosphingolipid -- agonists
- Rett Syndrome -- drug therapy
- Sphingosine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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