Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.

Deogracias, Rubén

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Aug 2012 - 14230-5 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1091-6490

10.1073/pnas.1206093109 doi


Animals
Astrocytes--cytology
Brain-Derived Neurotrophic Factor--deficiency
Cell Death--drug effects
Cells, Cultured
Disease Models, Animal
Excitatory Amino Acid Agonists--toxicity
Female
Fingolimod Hydrochloride
Immunosuppressive Agents--pharmacology
MAP Kinase Signaling System--drug effects
Methyl-CpG-Binding Protein 2--genetics
Mice
Motor Activity--drug effects
N-Methylaspartate--toxicity
Neurons--cytology
Organ Culture Techniques
Pregnancy
Propylene Glycols--pharmacology
Receptors, Lysosphingolipid--agonists
Rett Syndrome--drug therapy
Sphingosine--analogs & derivatives