An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis. [electronic resource]
Producer: 20130122Description: 1528-39 p. digitalISSN:- 1878-4186
- Amino Acid Motifs
- Amino Acid Substitution
- Animals
- Catalytic Domain
- Crystallography, X-Ray
- Enzyme Activation
- Guanosine Triphosphate -- chemistry
- HEK293 Cells
- HeLa Cells
- Homeostasis
- Humans
- Hydrogen Bonding
- Hydrolysis
- Kinetics
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Models, Molecular
- Monomeric GTP-Binding Proteins -- chemistry
- Multiprotein Complexes
- Mutagenesis, Site-Directed
- Neuropeptides -- chemistry
- Protein Binding
- Proteins -- metabolism
- Ras Homolog Enriched in Brain Protein
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- TOR Serine-Threonine Kinases
- Thermodynamics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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