An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis.
Mazhab-Jafari, Mohammad T
An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis. [electronic resource] - Structure (London, England : 1993) Sep 2012 - 1528-39 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1878-4186
10.1016/j.str.2012.06.013 doi
Amino Acid Motifs
Amino Acid Substitution
Animals
Catalytic Domain
Crystallography, X-Ray
Enzyme Activation
Guanosine Triphosphate--chemistry
HEK293 Cells
HeLa Cells
Homeostasis
Humans
Hydrogen Bonding
Hydrolysis
Kinetics
Mechanistic Target of Rapamycin Complex 1
Mice
Models, Molecular
Monomeric GTP-Binding Proteins--chemistry
Multiprotein Complexes
Mutagenesis, Site-Directed
Neuropeptides--chemistry
Protein Binding
Proteins--metabolism
Ras Homolog Enriched in Brain Protein
Ribosomal Protein S6 Kinases, 70-kDa--metabolism
TOR Serine-Threonine Kinases
Thermodynamics
An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis. [electronic resource] - Structure (London, England : 1993) Sep 2012 - 1528-39 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1878-4186
10.1016/j.str.2012.06.013 doi
Amino Acid Motifs
Amino Acid Substitution
Animals
Catalytic Domain
Crystallography, X-Ray
Enzyme Activation
Guanosine Triphosphate--chemistry
HEK293 Cells
HeLa Cells
Homeostasis
Humans
Hydrogen Bonding
Hydrolysis
Kinetics
Mechanistic Target of Rapamycin Complex 1
Mice
Models, Molecular
Monomeric GTP-Binding Proteins--chemistry
Multiprotein Complexes
Mutagenesis, Site-Directed
Neuropeptides--chemistry
Protein Binding
Proteins--metabolism
Ras Homolog Enriched in Brain Protein
Ribosomal Protein S6 Kinases, 70-kDa--metabolism
TOR Serine-Threonine Kinases
Thermodynamics