Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. [electronic resource]
Producer: 20121008Description: 3081-94 p. digitalISSN:- 1098-5549
- AMP-Activated Protein Kinases -- deficiency
- Animals
- Apoptosis
- Basic Helix-Loop-Helix Transcription Factors -- biosynthesis
- Cell Line
- Fumarate Hydratase -- deficiency
- Fumarates -- metabolism
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- biosynthesis
- Kidney Neoplasms -- genetics
- Leiomyomatosis -- genetics
- Mice
- Mitogen-Activated Protein Kinase 1 -- biosynthesis
- Mitogen-Activated Protein Kinase 3 -- biosynthesis
- Neoplastic Syndromes, Hereditary -- genetics
- RNA Interference
- RNA, Small Interfering
- Reactive Oxygen Species -- analysis
- Signal Transduction
- Skin Neoplasms
- Tumor Suppressor Proteins -- deficiency
- Uterine Neoplasms
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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