Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.

Bardella, Chiara

Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. [electronic resource] - Molecular and cellular biology Aug 2012 - 3081-94 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1098-5549

10.1128/MCB.06160-11 doi


AMP-Activated Protein Kinases--deficiency
Animals
Apoptosis
Basic Helix-Loop-Helix Transcription Factors--biosynthesis
Cell Line
Fumarate Hydratase--deficiency
Fumarates--metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--biosynthesis
Kidney Neoplasms--genetics
Leiomyomatosis--genetics
Mice
Mitogen-Activated Protein Kinase 1--biosynthesis
Mitogen-Activated Protein Kinase 3--biosynthesis
Neoplastic Syndromes, Hereditary--genetics
RNA Interference
RNA, Small Interfering
Reactive Oxygen Species--analysis
Signal Transduction
Skin Neoplasms
Tumor Suppressor Proteins--deficiency
Uterine Neoplasms