Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas. [electronic resource]
Producer: 20120625Description: 1367-73 p. digitalISSN:- 1532-1827
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal, Humanized -- pharmacology
- Breast Neoplasms -- diagnosis
- Drug Resistance, Neoplasm -- drug effects
- ErbB Receptors -- metabolism
- Female
- Humans
- Middle Aged
- Neoplasm Staging
- PTEN Phosphohydrolase -- metabolism
- Phosphatidylinositol 3-Kinases -- genetics
- Prognosis
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptor, ErbB-2 -- genetics
- Receptor, IGF Type 1 -- metabolism
- Signal Transduction -- drug effects
- Survival Analysis
- Trastuzumab
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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