Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas.
Gallardo, A
Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas. [electronic resource] - British journal of cancer Apr 2012 - 1367-73 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1532-1827
10.1038/bjc.2012.85 doi
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal, Humanized--pharmacology
Breast Neoplasms--diagnosis
Drug Resistance, Neoplasm--drug effects
ErbB Receptors--metabolism
Female
Humans
Middle Aged
Neoplasm Staging
PTEN Phosphohydrolase--metabolism
Phosphatidylinositol 3-Kinases--genetics
Prognosis
Proto-Oncogene Proteins c-akt--metabolism
Receptor, ErbB-2--genetics
Receptor, IGF Type 1--metabolism
Signal Transduction--drug effects
Survival Analysis
Trastuzumab
Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas. [electronic resource] - British journal of cancer Apr 2012 - 1367-73 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1532-1827
10.1038/bjc.2012.85 doi
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal, Humanized--pharmacology
Breast Neoplasms--diagnosis
Drug Resistance, Neoplasm--drug effects
ErbB Receptors--metabolism
Female
Humans
Middle Aged
Neoplasm Staging
PTEN Phosphohydrolase--metabolism
Phosphatidylinositol 3-Kinases--genetics
Prognosis
Proto-Oncogene Proteins c-akt--metabolism
Receptor, ErbB-2--genetics
Receptor, IGF Type 1--metabolism
Signal Transduction--drug effects
Survival Analysis
Trastuzumab