First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. [electronic resource]
Producer: 20120606Description: 11810-9 p. digitalISSN:- 1083-351X
- Alanine -- analogs & derivatives
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Peptides -- biosynthesis
- Amyloid beta-Protein Precursor -- metabolism
- Animals
- Azepines -- chemistry
- Binding, Competitive
- Brain -- drug effects
- Carbamates -- pharmacology
- Cell-Free System
- Dibenzazepines -- pharmacology
- Dipeptides -- pharmacology
- Drug Interactions
- Female
- Flurbiprofen -- pharmacology
- Guinea Pigs
- HEK293 Cells
- Humans
- Imidazoles -- pharmacology
- Mice
- Mice, Inbred C57BL
- Piperidines -- pharmacology
- Protein Binding
- Protein Processing, Post-Translational -- drug effects
- Pyrans -- chemistry
- Pyridines -- chemistry
- Pyrimidines -- chemistry
- Rats
- Receptor, EphA4 -- metabolism
- Receptor, EphB2 -- metabolism
- Receptors, Notch -- metabolism
- Sulfonamides -- pharmacology
- Sulindac -- analogs & derivatives
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Publication Type: Journal Article
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