Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions. [electronic resource]
Producer: 20120823Description: 919-27 p. digitalISSN:- 1521-009X
- Administration, Oral
- Animals
- Antineoplastic Agents -- administration & dosage
- Autoradiography
- Azetidines -- administration & dosage
- Bile -- metabolism
- Brain -- metabolism
- Cell Line, Tumor
- Cell Membrane -- metabolism
- Cell Membrane Permeability
- Colorectal Neoplasms -- drug therapy
- Dogs
- Dose-Response Relationship, Drug
- Female
- Humans
- Injections, Intravenous
- Macaca fascicularis
- Male
- Mice
- Mice, Nude
- Microsomes, Liver -- metabolism
- Models, Biological
- Piperidines -- administration & dosage
- Predictive Value of Tests
- Prospective Studies
- Protein Kinase Inhibitors -- administration & dosage
- Rats
- Rats, Long-Evans
- Rats, Sprague-Dawley
- Retrospective Studies
- Species Specificity
- Tissue Distribution
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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