Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.

Choo, Edna F

Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals May 2012 - 919-27 p. digital

Publication Type: Journal Article

1521-009X

10.1124/dmd.111.043778 doi


Administration, Oral
Animals
Antineoplastic Agents--administration & dosage
Autoradiography
Azetidines--administration & dosage
Bile--metabolism
Brain--metabolism
Cell Line, Tumor
Cell Membrane--metabolism
Cell Membrane Permeability
Colorectal Neoplasms--drug therapy
Dogs
Dose-Response Relationship, Drug
Female
Humans
Injections, Intravenous
Macaca fascicularis
Male
Mice
Mice, Nude
Microsomes, Liver--metabolism
Models, Biological
Piperidines--administration & dosage
Predictive Value of Tests
Prospective Studies
Protein Kinase Inhibitors--administration & dosage
Rats
Rats, Long-Evans
Rats, Sprague-Dawley
Retrospective Studies
Species Specificity
Tissue Distribution
Xenograft Model Antitumor Assays