Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain. [electronic resource]
Producer: 20120917Description: 951-60 p. digitalISSN:- 1875-8908
- Aging -- metabolism
- Amyloid beta-Protein Precursor -- antagonists & inhibitors
- Animals
- Brain -- drug effects
- Drug Delivery Systems
- Gene Expression Regulation
- Low Density Lipoprotein Receptor-Related Protein-1
- Male
- Mice
- Mice, Transgenic
- Oligonucleotides, Antisense -- administration & dosage
- Receptors, LDL -- antagonists & inhibitors
- Tumor Suppressor Proteins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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